Alpha2B-Adrenergic Receptor Overexpression in the Brain Potentiate Air Pollution-induced Behavior and Blood Pressure Changes
نویسندگان
چکیده
منابع مشابه
Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response.
Exaggerated response to alpha2-adrenergic receptor (alpha2-AR) blockade by yohimbine in normotensive subjects is an intermediate phenotype that predicts increased risk for development of hypertension. Here, we assessed the 3 alpha2-AR loci (alpha2A, alpha2B, alpha2C) as candidate genes for their influence on baseline and yohimbine-mediated increase in mean arterial pressure. Because initial res...
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BACKGROUND Epidemiologic studies suggest a positive association between fine particulate matter and arterial blood pressure, but the results have been inconsistent. OBJECTIVES We investigated the effect of ambient particles on systemic hemodynamics during a 5-hr exposure to concentrated ambient air particles (CAPs) or filtered air (FA) in conscious canines. METHODS Thirteen dogs were repeat...
متن کاملRole of the alpha2B-adrenergic receptor in the development of salt-induced hypertension.
Salt sensitivity is a common trait in patients with essential hypertension and seems to have both an inherited and an acquired component (eg, is influenced by aging and renal insufficiency). Experimental evidence suggests that salt loading induces hypertension via a neurogenic mechanism mediated by the alpha2-adrenergic receptors (alpha2-AR). To explore the alpha2-AR subtype involved in this me...
متن کاملChronology of blood pressure changes in renal hypertension induced by solid plexiglass clips in the rat
The objective of this study was to determine the chronology of changes in blood pressure in renalhypertension induced by solid plexiglass clips in rats. Saw blades with the thickness of 0.21-0.22 mm wereused to make clips sized 4 × 2 × 2 mm from a piece of 2-mm thick plexiglass. Rats were subjected to shamoperation or left renal arterial clipping, and 1, 2, 3 and 4 weeks later blood pressure, a...
متن کاملAir Pollution and Blood Pressure Insights Into the Mechanisms and Mediators of the Effects of Air Pollution Exposure on Blood Pressure and Vascular Function in Healthy Humans
Fine particulate matter air pollution plus ozone impairs vascular function and raises diastolic blood pressure. We aimed to determine the mechanism and air pollutant responsible. The effects of pollution on heart rate variability, blood pressure, biomarkers, and brachial flow-mediated dilatation were determined in 2 randomized, double-blind, crossover studies. In Ann Arbor, 50 subjects were exp...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2019
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfz025